| dc.contributor.advisor | | |
| dc.contributor.author | HARDIANTO, HENDRIAN ADE | |
| dc.date.accessioned | 2017-08-09T02:05:03Z | |
| dc.date.available | 2017-08-09T02:05:03Z | |
| dc.date.issued | 2017-12-30 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/12630 | |
| dc.description | Backgrounds: Congenital hypothyroidism is a deficiency of thyroid hormones since in the womb. Congenital hypothyroidism can be prevented through early diagnosis, then treated with levo-thyroxine (L-T4). However, such screening has not been a routine government program so levothyroxine replacement therapy has not been effective. So the need for a supply of foods containing lots of iodine should be encouraged. Bloated fish (Rastrelliger sp) is thought to increase serum FT4 levels in congenital hypothyroid patients because it is rich in iodine, phenylalanine and other nutrients.
Methods: Pure experimental design with post test controlled group design on test animals. The subjects consisted of 30 rats divided randomly in 6 groups consisting of normal control group, normal bloated fish supplement, hypothyroidism, hypothyroidism bloated fish supplement, and hypothyroid thyroid therapy with bloated fish supplement.
Result: The mean serum FT4 concentration in the hypothyroid mice group was 0.50 ng / dL significantly lower with the other groups. The mean serum FT4 concentrations of the group of bloated fish supplements in normal mice was 1.09 ng / dL did not increase significantly, whereas the mean serum FT4 level of supplementation of bloated fish in the hypothyroid group was 0.72 ng / dL significantly increased Although not to the limit of normal, and mean serum FT4 levels of supplemental bloated fish and thyroxine therapy simultaneously in hypothyroid group rats was 1.11 ng / dL significantly decreased.
Conclusion: Giving mackerel in hypothyroid rats significantly increase serum FT4 levels, while supplementation mackerel in hypothyroid rats were treated with thyroxine provides the barrier effect. | en_US |
| dc.description.abstract | Latar Belakang: Hipotiroid kongenital merupakan kekurangan hormon tiroid sejak dalam kandungan. Hipotiroid kongenital dapat dicegah melalui diagnosis dini, kemudian diberikan terapi dengan levo-tiroksin (L-T4). Akan tetapi skrining tersebut belum menjadi program rutin pemerintah sehingga terapi pengganti levotiroksin belum efektif. Maka perlunya suplai makanan yang banyak mengandung iodium perlu digalakkan. Ikan kembung (Rastrelliger sp) diduga dapat meningkatkan kadar FT4 serum pada penderita hipotiroid kongenital karena kaya akan kandungan iodium, fenilalanin serta nutrisi lainnya.
Metode: Eksperimental murni yang dilakukan dengan rancangan post test controlled group design terhadap hewan uji. Subjek penelitian terdiri dari 30 ekor tikus yang dibagi secara acak dalam 6 kelompok yang terdiri dari kelompok kontrol normal, normal suplemen ikan kembung, hipotiroid, hipotiroid suplemen ikan kembung, dan hipotiroid terapi tiroksin dengan suplemen ikan kembung.
Hasil: Kadar rata-rata FT4 serum pada kelompok tikus hipotiroid adalah 0,50 ng/dL lebih rendah secara signifikan dengan kelompok lainnya. Kadar rata-rata FT4 serum kelompok pemberian suplemen ikan kembung pada tikus normal adalah 1,09 ng/dL tidak meningkat secara signifikan, sedangkan kadar rata-rata FT4 serum pemberian suplemen ikan kembung pada kelompok hipotiroid adalah 0,72 ng/dL meningkat secara signifikan meskipun tidak sampai batas normal, dan kadar rata-rata FT4 serum pemberian suplemen ikan kembung dan terapi tiroksin secara bersamaan pada tikus kelompok hipotiroid adalah 1,11 ng/dL menurun secara signifikan.
Kesimpulan: Pemberian ikan kembung pada tikus hipotiroid meningkatkan secara signifikan kadar FT4 serum sedangkan pemberian suplemen ikan kembung pada tikus hipotiroid yang mendapat terapi tiroksin memberikan efek hambatan. | en_US |
| dc.publisher | FKIK UMY | en_US |
| dc.subject | hipotiroid kongenital, ikan kembung, kadar FT4 serum. congenital hypothyroidism, mackerel,FT4 serum | en_US |
| dc.title | UJI POTENSI IKAN KEMBUNG (Rastrellinger sp) TERHADAP KADAR FT4 SERUM PADA TIKUS PUTIH HIPOTIROID KONGENITAL | en_US |
| dc.type | Thesis
SKR
FKIK
483 | en_US |
