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dc.contributor.authorJENIE, IKHLAS MUHAMMAD
dc.contributor.authorGUGUN, ADANG MUHAMMAD
dc.date.accessioned2017-08-25T23:20:03Z
dc.date.available2017-08-25T23:20:03Z
dc.date.issued2016-12
dc.identifier.issn978-979-3232-24-9
dc.identifier.urihttp://repository.umy.ac.id/handle/123456789/13449
dc.description.abstractBackgrounds: Platelets adhesion, activation, and aggregation play an important role in cardiovascular pathogenesis. These events emerge as consequences of the endothelial dysfunction and activation. Hypertension is known as a risk factor for cardiovascular disease. Aim: To know whether endothelial dysfunction and activation have been occurred in prehypertension subjects. Methods: We did a quasi experimental, ex vivo, human study, by examining platelet aggregation using the turbidimetric method in 10 undergraduate students with a family history of hypertension and 10 undergraduate students without a family history of hypertension. Results: The two groups did not differ significantly in gender proportion, age, body mass index, resting blood pressure, and platelets counting. The two groups did not differ significantly in the percentage of maximal platelet aggregation to 2, 5, and 10 µM adenosine 5’-diphosphate (ADP). These results showed that normotensive subjects with family history of hypertension do not have exaggerated platelets reactivity as compared to their counterparts. Conclusion: Under resting condition endothelial dysfunction may not manifest yet in the form of increased platelets aggregation in normotensive subjects with a family history of hypertension. Relevance for patients: Normotensive subjects with a family history of hypertension can be considered as prehypertension subjects. To prevent the development of hypertension in these subjects and its collateral events, we need to explore the structural and functional changes in their cardiovascular system.en_US
dc.description.sponsorshipFaculty of Medicine and Health Sciences Universitas Muhammadiyah Yogyakartaen_US
dc.language.isoenen_US
dc.publisherUniversitas Islam Indonesiaen_US
dc.subjectPlatelets reactivityen_US
dc.subjectPrehypertensionen_US
dc.subjectNormotensive subjectsen_US
dc.subjectA family history of hypertensionen_US
dc.subjectEndothelial dysfunctionen_US
dc.titleA PRELIMINARY STUDY ON PLATELET REACTIVITY IN NORMOTENSIVE SUBJECTS WITH A FAMILY HISTORY OF HYPERTENSIONen_US
dc.typeArticleen_US


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    Berisi artikel ilmiah (bukan sertifikat) yang ditulis oleh dosen pada acara konferensi baik lokal, nasional maupun internasional dengan penyelenggara dari luar UMY, baik sebagai peserta Call for Paper, presenter, narasumber maupun keynote speaker.

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