|dc.description.abstract||Dysentery is diarrhea disease with liquid bladder and spotting blood that caused
by bacteria infection. The height of incidence of this disease in Indonesia was
caused by genus Shigella. Indonesia used many plants as traditional medicine.
One the medical plants, that is often used is mahagoni seeds (Swietenia mahagoni
fructus). This study was conducted to determine activity of anti-bacteria of
mahagoni seeds extract toward bacteria Shigella sp.
Extraction of this research is done by using infuses method and percolation
method with a solvent of water and ethanol. The extract obtained is made into
variation of concentration which will be used as sample for next test of antibacteria
activity. The test of anti-bacteria activity in this research was researched
by using Kirby-Bauer method or disk diffusion. The identification of secondary
metabolite compound that are suspected to have activity of anti-bacteria done
quantitatively by using phytochemical analysis test.
The results of identification antibacterial compound shows that there are positive
contain alkaloids and saponins in all water extracts and ethanol extracts. The
result of antibacterial activity shows that on the water extract by infundation and
percolation method does not show inhibition zone or clear zone, while in ethanol
extracts that used percolation method at concentration 25%, 50%, 75% and 100%
proved if there are anti-bacteria activity toward Shigella sp. that showed inhibition
zone or clear zone in agar plate. Minimal concentration of ethanol extracts that
can inhibit the growth of bacteria is 25% with 5,6 mm diameter and 100%
concentration have high inhibition zone with 8,9 mm diameter. Based on zone
classification of inhibition zone activity, ethanol extracts mahagoni seeds included
in the category of weak in inhibiting the growth of bacteria.||en_US