| dc.contributor.advisor | | |
| dc.contributor.author | KARTIKA, PRAMUDITA ANGGA | |
| dc.date.accessioned | 2018-03-31T07:52:05Z | |
| dc.date.available | 2018-03-31T07:52:05Z | |
| dc.date.issued | 2015 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/18374 | |
| dc.description | Liver is the central metabolism and detoxification. Alcoholic hepatitis is a
syndrome of inflammation of the liver, which generally occurs due to alcohol
consumption progressively over a long period of time. Centela asiatica is a plant
that believe to be hepatoprotector because there is antioxidant subtance . The
purpose of this study was to examine the effectiveness of extract pegagan (Centela
asiatica) in the rehabilitation of alcoholic liver in mice (Mus musculus) through
observation of SGOT and SGPT.
This study is pure experimental with pretest posttest control group design.
Subject posttest control group research are mice (Mus musculus) androgynous male
Swiss Webster age of 2-3 months with weight + 20 grams, totaling 30 subject were
randomized into 6 groups, each group consisted of 5 mice. Alcoholic induction by
red wine 14.7% as much as 1.12 mg / 20g BB orally 1 time a day for 21 days.
Extract pegagan (Centela asiatica) was administered orally in accordance with the
group. Sampling SGOT and SGPT done 3 times through orbital vein. The data was
analyzed by one-way ANOVA followed Tuckey HSD test.
Induction of 14,7% alcohol cause liver damage, evident from the significant
increase is in the levels of SGOT and SGPT enzymes (p = 0,000). Induction of
Centella asiatica leaf extract (Centella asiatica) has been shown to reduce levels of
SGOT and SGPT enzymes (P = 0,000). SGPT value decrease of 13,10 IU/L
and SGOT of 12,04 IU/L with Tuckey HSD test showed the effectiveness of
Centella asiatica leaf extract (Centella asiatica) in improving liver function. | en_US |
| dc.description.abstract | Liver is the central metabolism and detoxification. Alcoholic hepatitis is a
syndrome of inflammation of the liver, which generally occurs due to alcohol
consumption progressively over a long period of time. Centela asiatica is a plant
that believe to be hepatoprotector because there is antioxidant subtance . The
purpose of this study was to examine the effectiveness of extract pegagan (Centela
asiatica) in the rehabilitation of alcoholic liver in mice (Mus musculus) through
observation of SGOT and SGPT.
This study is pure experimental with pretest posttest control group design.
Subject posttest control group research are mice (Mus musculus) androgynous male
Swiss Webster age of 2-3 months with weight + 20 grams, totaling 30 subject were
randomized into 6 groups, each group consisted of 5 mice. Alcoholic induction by
red wine 14.7% as much as 1.12 mg / 20g BB orally 1 time a day for 21 days.
Extract pegagan (Centela asiatica) was administered orally in accordance with the
group. Sampling SGOT and SGPT done 3 times through orbital vein. The data was
analyzed by one-way ANOVA followed Tuckey HSD test.
Induction of 14,7% alcohol cause liver damage, evident from the significant
increase is in the levels of SGOT and SGPT enzymes (p = 0,000). Induction of
Centella asiatica leaf extract (Centella asiatica) has been shown to reduce levels of
SGOT and SGPT enzymes (P = 0,000). SGPT value decrease of 13,10 IU/L
and SGOT of 12,04 IU/L with Tuckey HSD test showed the effectiveness of
Centella asiatica leaf extract (Centella asiatica) in improving liver function. | en_US |
| dc.publisher | FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS MUHAMMADIYAH YOGYAKARTA | en_US |
| dc.subject | Alcoholic hepatitis, SGOT, SGPT, Centela asiatica | en_US |
| dc.title | EFEKTIFITAS EKSTRAK DAUN PEGAGAN DALAM REHABILITASI FUNGSI HEPAR MENCIT HEPATITIS ALKOHOLIK MELALUI HASIL PENGAMATAN SGOT DAN SGPT | en_US |
| dc.type | Thesis | en_US |
