| dc.description.abstract | Backgrounds: Platelets adhesion, activation, and aggregation play
an important role in cardiovascular pathogenesis. These events emerge as
consequences of the endothelial dysfunction and activation. Hypertension is
known as a risk factor for cardiovascular disease.
Aim: To know whether endothelial dysfunction and activation have been
occurred in prehypertension subjects.
Methods: We did a quasi experimental, ex vivo, human study, by examining
platelet aggregation using the turbidimetric method in 10 undergraduate students
with a family history of hypertension and 10 undergraduate students without a
family history of hypertension.
Results: The two groups did not differ significantly in gender proportion,
age, body mass index, resting blood pressure, and platelets counting. The
two groups did not differ significantly in the percentage of maximal platelet
aggregation to 2, 5, and 10 µM adenosine 5’-diphosphate (ADP). These results
showed that normotensive subjects with family history of hypertension do not
have exaggerated platelets reactivity as compared to their counterparts.
Conclusion: Under resting condition endothelial dysfunction may not
manifest yet in the form of increased platelets aggregation in normotensive
subjects with a family history of hypertension.
Relevance for patients: Normotensive subjects with a family history of
hypertension can be considered as prehypertension subjects. To prevent the
development of hypertension in these subjects and its collateral events, we need
to explore the structural and functional changes in their cardiovascular system. | en_US |
