Background : Green Tobacco Sickness (GTS) is one of the risk of health and safety at work suffered by tobacco pickers. This disease occurs through skin exposure to nicotine in tobacco leaves are still wet. ‘I’he main livelihood of the villagers Legoksari are tobacco farmers, with presentation 100 percent of the population are tobacco farmers too. The purpose of this study was to know about risk factors of GTS among the tobacco pickers at Legoksari Village, Tlogomulyo Subdistrick, Temanggung Districk, Province of Central Java, Indonesia. Method : This type and design of research was cross sectional study. The sample size in this study are 108 respondents. Sampling method used non-probability sampling with purposive sampling. Data taken with quistionnaire and check-list. The variables examined in this research include duration of work, smoking habbit, and the used of personal protection device. - Result : Results showed that of 108 respondents found 38 tobacco pickers (35,2%) had positive GTS and 70 tobacco pickers (64,8%) had negative GTS. Bivariate analysis showed a relationship between smoking habbit with incidence of GTS (P Value 0,001 and RP = 3,188). There was not statistically significant relationship between duration of work (P Value = 0,282 and RP = 1,944) and the used of personal protection device (P Value 0,05 and RP = 1,653). Conclusion : There is a statistically significant relationship between smoking habit with incidence of GTS but in the other hand there is no statistically significant relationship between duration of work and the used of self protection device.