As the member of European Union, United Kingdom relations with European Union is not always good. United Kingdom has their national interest for their guidelines in every decision making procees. Although, United Kingdom got many advantage from economic sides. In the other side, the more integrated European Union, the more power they have to make a regulation over their member.After 43 year United Kingdom’s membership of European Union, thay bust up with 2016 Referendum. The referendum was held due to the demand of United Kingdom Independence Party since 2005 and Conservative Prime Minister, David Cameroon promise on his 2015 campaign. Vote Leave Group Campaign take a part in the referendum campaign with their main tagline about “take back control” of United Kingdom immigration and sovereignty. The referendum are affected by British and European Union unstable relations over last decade.