Diabetic neuropathy is the most important and commonest diabetic complication, afflicting over 50% of all diabetics. Center of Indonesia’s data and information informed, during 2011, diabetic neuropathy affects >50% of diabetic patients with amputation numbers ranging from 15-30%. These problems led to a high number of disabilities, declining productivity and huge costs. Multiple pathogenic of hyperglycemia contribute to diabetic complications. Additional experiments indicate that diabetic neuropathy is not simply the result of nerve cells being damaged directly by hyperglycemia. The clinical manifestations, underlying pathology and aetiology are varied and complex. There remains much debate and controversy to prove effective treatments for diabetic neuropathy. To uncovered these problems, we did some studies in 2007-2015 with the objective to determine a good approach to treat diabetic neuropathy. Since the research about “Corelation among the duration of suffering DM and diabetic neuropathy degree”, “Comparation of diabetic neuropathy degree based on the state of diabetes”, “Management of ulcus diabeticum - a study of antibiotics and diet counseling effectivity”, “Efficacy of diabetic foot exercise in the diabetic neuropathy based on the diabetic neuropathy scale and the diabetic neuropathy examination”, “Susceptibility pattern and antibiotic therapeutic effectivity”, “Pattern development of diabetic foot”, “Pattern of serum levels changes of nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 after performing diabetic foot exercise”, and “Diabetic foot exercise induced serum neurotrophin-3 in diabetic neuropathy”. Those studies and some other data shown a peripheral effect of intervention can be a good chance for diabetic neuropathy therapeutic strategies in the future.