Background: Osteoarthritis (OA) is a degenerative joint disease associated with cartilage damage joints and cause disability. The diagnosis of OA can be established based on clinical symptoms, laboratory findings, and radiological examination. The prevalence and incidence of knee OA is affected by the difference between the sexes. The prevalence and severity of knee OA were significantly higher in older women than in older men. This study is required to describe the distinctive characteristic features of radiological osteoarthritis of the knee based on the difference between the sexes. Methods: The study sampel as many as 57 people suffering from osteoarthritis genu and willing to do plain in Radiology Hospital Tidar Magelang City. Analysis of the data used by the analytical test contingency correlation coefficient to determine the relationship of gender to the severity of OA according to Kellgren-Lawrence classification. Results: The number of respondents as many as 57 people with as many as 37 women and 20 men, then interpreted the severity according to Kellgren-Lawrence, in women the highest number contained in the first degree (dubious), whereas in males the highest at 2 degrees (minimum). Conclusion:There is a relationship between gender and severity of knee OA were classified according to the table Kellgren-Lawrence. The characteristics of radiology picture of OA is most in men is the presence of osteophytes, while in women the most common characteristics of the narrowing gap joints.