Background Over twenty one million people in Indonesia were estimated to be become diabetic by year 2030. The rates of both obesity and diabetes mellitus are high on the worlwide. The goal of this study was to describe the relationship of obesity and diabetic peripheral neuropathy (DPN) in persons with diabetes mellitus. Research Methods A cross-sectional analysis of obesity and diabetic peripheral neuropathy (DPN) was conducted among 62 diabetic subjects in RSUD Kota Yogyakarta, who were grouped based on presence or absence of DPN. DPN was determined only by questioner of Diabetic Neuropathy Symptom (DNS-Score). Results Twenty eight of the diabetic persons had peripheral neuropathy (45,16%); 25 persons were woman (89,29%), 3 persons were man (10,71%), 3 persons were age<55 years (10,71%), 25 persons were age≥55 years (89,29%), 6 persons had duration of DM<5 years (21,43%), 22 persons had duration of DM≥5 years (78,57%), 14 persons had obesity (50%) and 14 persons had no obesity (50%). After data analysis was conducted, obtained result p >0,05 (p=0,818). Conclusion The result can be concluded that obesity had no association with diabetic peripheral neuropathy.