This research aimed to identify (i). the IGF-1 and IGFBP-3 level of ESRD and non ESRD populations in Indonesia and (ii). The correlation between IGF-1 and IGFBP-3 level and ESRD incidences.This case control study was carried out in Yogyakarta among 159 volunteers. The result showed that among respondents whose data were successfully and completely collected involved 159 volunteers. The result of bivariate analysis showed level, IGF-1 and IGFBP-3 plasma level, DM history and hypertensive illness history had correlation with ESRD incidences. Lower IGF-1 level and higher IGFBP-3 level have highest OR value and can be used as predictor biomar ESRD incidence. Based on the research result, it is concluded that there difference in IGF-1 and IGFBP-3 plasma level between ESRD and non- ESRD patients in Indonesia. The IGF-1 and IGFBP-3 plasma level have correlation with ESRD incidence in Indonesia.