Hemodialysis is an ongoing treatment and takes in the long term. One of the complications of hemodialysis is interdialytic weight gain-IDWG and in uences quality of life. Physical and psychological health dimension become focus in this research because both dimensions have more in uence on morbidity and mortality. The objective of this study to determine the correlation IDWG and physical and psychological health to quality of life in patients with hemodialysis. Cross-sectional study with samples of 66 patients in Hemodialysis Unit of PKU Muhammadiyah Gamping Hospital from September to October 2016. Quality of life in patients with hemodialysis was examined using questionnaires of WHOQOL-BREF. Results showed that 54.5% of patients with hemodialysis had IDWG in the average category. It showed that IDWG in uenced physical health (p=0.002) and psychological health (p=0.000) to quality of life in patients with hemodialysis. IDWG in uenced physical and psychological health in quality of life in patients with hemodialysis.