Mostly patient with ESRD choosed Renal replacement therapy hemodialysis. On the other hand, hemodialysis was known which had negative affect on quality of life. Comorbidity was one of the factors that affected quality of life (QOL) in patients with hemodialysis. Hypertension was known as the highest comorbidity in patients with hemodialysis. This study evaluated QOL in hypertension patients on maintenance hemodialysis therapy. This method of this research is prospective cohort study was used and The QOL index was measured by the WHOQoL-BREF questionnaire. 79 samples on hemodialysis unit in PKU Muhammadiyah Yogyakarta hospital were collected during March to May 2016. The result showed that comorbid hypertension affected the quality of life patients with hemodialysis. Patients with hemodialysis without comorbid hypertension had a good QOL 4,7 times than patients with hypertension comorbidity Hypertension were known as factors that affected quality of life patients with hemodialysis.