Compliance to standard precautions is still low including hand hygiene, PPE, sharps injury prevention and instrument sterilization. The dental health practitioners should comply in implementing standard precautions in dental health service. The aim to describing the compliance level of dental health practitioners in implementing standard precautions, analyzing the in uence of factors associated with compliance in the implementation of standard precautions. The study used a mixed method. Quantitative was applied using observation quantitative with survey approach and cross sectional design, qualitative method with a case study approach. Population consisted of all dental health practitioners. The data required were collected by using interviews, questionnaires, observations, documentary study. Quantitative data analysis used multiple linear regression. The compliance level based on the questionnaire for 9 elements show that the dental health practitioners have mostly been compliant with elements of standard precautions (83,39%). There was a signi cant in uence between the factors associated with compliance to the implementation of standard precautions (98,3%). Result of the observations: 22.52% were not compliant in implementing standard precautions. Result of the interviews: moments and procedures for hand hygiene were not applied properly; PPE, the safety goggles was not available; the health workers who have not been vaccinated during working. Y=16,144 + 1,129X1 + (-)0,145X2 + (-)743X3 + 0,202X4 + 0,883X5 + (-)0,226X6 + 0,053X7, R=0,992; R2=0,983; F=0,925; p=0,000. There were the dental health practitioners who were not honest in giving answers on questionnaires and still do not comply in implementing standard precautions; there isthe in uence between the compliance factors with the implementation of standard precautions.