The implementation of community empowerment through alert village program in Ogan Ilir regency was not optimal. Morbidity rates of some aspects of public health such as maternal and child health as well as environmental health were still high. Stakeholders‘ knowledge are very essential to be analyzed as a step in order to implement effective alert village program. This study aimed to analyze the stakeholders’ knowledge regarding alert village program in Ogan Ilir regency. This was qualitative study. The research location is Ogan Ilir regency. Informants were determined referring to the guidelines of active alert villages from MoH of Republic Indonesia. Informants consist of 29 people involved in the alert village program at level regency/district, sub-districts and villages. The data were primary data from in-depth interviews, direct observation and secondary data were collected through documents review. Basic health services in alert villages held in community health sub-center, village health post and integrated health post including health services for pregnant women, breastfeeding mothers, children, elderly and patients. Stakeholders obtained information concerning alert village program from several sources. Most of the information was obtained through dissemination activities organized by the provincial health department and district health of ces. In general, stakeholders’ knowledge was good and it must be also expanded through facilitating information exchange among stakeholders.