High Maternal Mortality Rate (MMR) still a problem in the world. One contributing factor is the infection caused by Premature Rupture of Membrane (PROM). Preterm (PPROM) and at Term (PROM) may increase a risk of infection at pregnant women. The younger gestational age at delivery process contributes to the longer latent period and increase the risk of maternal infection. Leukocytosis could be an indicator of the infection. This study aimed to compare the number of maternal leukocytosis incidence between PPROM and PROM. This study used observational comparative with cross-sectional study design. The samples in this study were medical records of pregnant women with PPROM and PROM in Panembahan Senopati Hospital, Bantul from January 2013-June 2015. Sampling was conducted by purposive sampling method with 66 samples which were divided into two groups: PPROM and PROM, with 33 samples for each. Data was analyzed using Chi-square test. The result of this study showed that there was no difference in the number of maternal leukocytosis incidence between Preterm and at Term PROM (p=0.741;RR=0.833;95% CI=0.282 to 2.464). Based on research results could be concluded that there was no difference in the number of maternal leukocytosis incidence between Preterm and at Term PROM.