Adverse effects of ambient air pollution in the environment, climate and public health has been recognized. Air pollution has an effect both acute and chronic human health, affecting a number of different systems and organs. This paper is to explain the effects of air pollution on human health and the mechanism of action brie y. The method used is a reviews of research papers and reports on air pollution and the effects on human health. Air pollution in the city of Palembang as big city comes from motor vehicles, especially of particulates matter. Particulate air pollution is important to attention as it affects the human respiratory system.