Pre-menstrual syndromeare an emotional and physical symptoms that happened before menstruation. The symptomsis caused by increasing of estrogen level. Sport activity is one of the treatment to decrease the pre-menstrual syndrome, because exercise can increase the endorphin that can prevent the increasing of estrogen. The aim of the study was to know the relationship between sport activity and pre-menstrual syndrome. The research was cross-sectional study. Respondents in this study were 66 students. They  ll out the questionnaire at the same time. Data were statistically analyzed by chi square test. The results of the study was 77.8% students who do exercise regularly were suffer moderate premenstrual syndrome and 54.4% the respondent who do not regularly exercise suffered severe premenstrual syndrome (p <0.05) The students who are exercise regularly have a risk to suffer moderate until severe premenstrual syndrome 3.786 times compared with students who regularly exercise. It was concluded that there is a relationship between sporting activity with the occurrence of premenstrual syndrome in female students at SMAN 1 Sentolo