Background: Nicotine and alcohol are both addictive substances that often used together. Current studies in the western countries show that 80-90% of the population who smoke, are drinking alcohol regularly compared with the general population, which is only 66%. Furthermore, smokers tend to be heavy drinkers than non-smokers. However, there are paucity of studies in regards of this relationship in Indonesia with a consideration of Indonesia as the country with the biggest Muslim population that prohibit alcohol consumption. Aim: the purpose of this study was to determine what factorsare in uencing smokers to consume alcoholic beverages among college students from one of a private university in Yogyakarta. Methods: a non-experimental study with analytic descriptive approach and cross sectionaldesign. Subjects were 170 university students in one of a private university in Yogyakarta who smoke and/or drink alcohol. This research wasconducted in May 2011 by distributing questionnaires on cigarettes smoking and alcohol consumption. Logistic regression is used to determine the correlation’s strength of predictor factors with SPSS version 15. Results: indicating that factors in uencing smokers to consume alcohol isunhealthy social condition (OR = 52. 521), the belief that drinking alcohol canreduce boredom and stres (OR = 16. 364), low self-esteem (OR = 9. 774), curiosity(OR = 6. 990), lack of achievement motivation (OR = 4. 679), adherence to worship(OR = 1. 788), and how to obtain recognition from her friends (OR = 1. 238). A qualitative study was considered important in exploring deeper into the underlying perceptions.