Total Knee Replacement (TKR) patients who will have limited motion in the knee function, weakness, immobility and disability as a result is the inability to care for themselves, the individual is not able to do daily activities as usual. This study was to determine the effect of education early mobilization of the level of anxiety and the degree of independence in patients with after TKR. Research are using quasi-experimental design with pre and post control group design, with 34 respondents (22 experimental group, 12 controls group). The sampling technique using consecutive sampling.The independent variable is education early mobilization, while the dependent variable are the level of independence and anxiety. The population were patients with after TKR in Prof. Dr. R. Soeharso Surakarta Orthopaedic Hospital and Surgery Main Karima Surakarta Hospital. Data were analyzed using independent t-test and paired t-test. There are signi cant differences in the level of independence and anxiety in patients before and after education early mobilization. The result of independent t-test on the level of anxiety was obtained p value (0.000) <0.05 and independent was p value 0,000, signi cant difference of anxiety and self-reliance in patients given education with patients who were not given education early mobilization. There is an increased independence and decreased anxiety in patients who underwent surgery after TKR education early mobilization.