Gempur batu kejibeling is a traditional medicine to cure the stone-renal very effective. Daily intake of infusa gempur batu kejibeling is suspected to induce the bleeding in intestinal for long term.This research was carried out to detect the in uence of intake extract gempur batu kejibeling for 9 week to the histological of digestive tract on female rat. The twenty rats were divided into 2 groups: as Group I Control and Group II daily intake 10 mg/200 grBB of extract gempur batu kejibeling for 9 weeks. Decapitation of rat was conduct to take the oesophagus, stomach/gastri, intestinum of rat. All the organs were kept in the container with the formalin 12 %. Hematoxylin eosin was used to identify the cell and tissue. The histological of oesophagus, gastric and intestinum was compared between control group and treatment group. The cell and tissue construct of oesophagus showed the normal histological. There was not any defect. The cell and tissue construct of gastric also intestinum showed the normal histological. The intake of extract gempur batu kejibeling (Strobilanthuscrispus,BL) dose 10 mg/200 gr BB during 9 week was not damage the histological of oesophagus, gastric and intestinum of rat.