The successes of European Union on integrating its regional has brought a realizaion of how advantageous a regional integration for a nation or states. And so does Africa which came into realization before agreeing to negotiate an agreement that will bring Africa to a whole regional integration. The idea that the Economic Partnership Agreement (EPA) will support regional integration has been one of the fundamental argument by European Union to persuade Africa of the value of this agreement. This research aims to explain the implication of EPA on African regional integration. In which the agreement and the whole negotiations processes are dealing with some facts that before EPA commit to help African integration, Africa itself has been developing regional integration and has been facing several challenges. So how exactly the play of EPA role within the region with its own regional integration challenges and problems.