Background: Tobacco epidemic is one of the biggest public health threats globally. The World Health Organization (WHO) developed MPOWER (monitoring-protecting-offering-warning-enforcing-raising) strategy to defeat the global tobacco epidemic. Smoking prevalence in Indonesia is ranked as the third highest in the world. Universitas Muhammadiyah Yogyakarta (UMY) declared itself as a smoke-free campus in 2011. However, many active smokers are still observed smoking on the campus. In order to support the global and local initiatives in defeating tobacco epidemic, a comprehensive smoking cessation program within UMY campus has recently been developed. Methods: After reviewing existing literature and considering available resources, UMY Firdaus Primary Care Clinic (Klinik Pratama Firdaus) has been preparing to provide comprehensive smoking cessation services. Results: Preparation of human resurces is conducted by sending several general practitioners and nurses working at Firdaus Clinic to attend several trainings and workshops on smoking cessation models. The program consists of five components: (1) Regular patient and public education at the clinic and campus about the danger of smoking; (2) Screening of tobacco use in every patient visit using the ABC approach; (3) Offering every active smoker to 5 A’s counseling alone or combined with SEFT or Spiritual-EFT (Spiritual Emotional Freedom Technique) therapy conducted individually; (4) Group intervention using the Quit Now 7 Steps for Freedom or SEFT therapy; and (5) Establishing self-help groups for smokers who are trying to quit smoking. Conclusion: Comprehensive smoking cessation program has been developed in Firdaus Clinic and ready to be provided to active smokers for supporting UMY as a smoke-free campus.