Background: Based on WHO 2012, in worldwide 60-90% of school children and nearly 100% of adults have dental caries which often causes pain and can affect quality of life, with varying prevalence and severity. Reseach objective: To know the correlation between dental caries status with quality of life (Oral Health Related Quality of Life) on Economics Students Muhammadiyah University of Yogyakarta Research methodology: This research is observational analytics using cross sectional design. Research subjects were 110 respondents taken using simple random sampling technique. The subject of this study is Economics Students Muhammadiyah University of Yogyakarta aged 20-21 years. Dental caries status was measured using the DMF-T index (WHO) while the quality of life impact was measured using OHIP-14 (WHO). Data analyzed using Spearman’s correlation. Reseach findings: Based on Spearman's test results, the correlation strength value (r) is 0.195 and p value is 0.041 (<0.05) so there is a significant correlation between dental caries status with quality of life (Oral Health Related Quality of Life) . Mean value of DMF-T is 5,5 (high) and OHIP-14 status is 59 % (worse). Conclusion: There is a significant correlation between dental caries status with quality of life (Oral Health Related Quality of Life) on Economics Students Muhammadiyah University of Yogyakarta, which the higher dental caries the worse the quality of life. Dental caries status on respondents is high and quality of life on respondents is worse.