Poverty is a very complex social problem and must be given an appropriate handling in order to be resolved soon. This is proved by the large number of poor people. The purpose of this research is to analyze the effect of population, education and also unemployment of poverty in West Nusa Tenggara. The research was done using data secondary in the form of panel of cross time period 2012-2015 and cross place ten districts in West Nusa Tenggara. The method used estimate this regression model was the Fixed Effect Model (FEM). The regression showed that the variabel of population has positive and significant effect on the poverty. Meanwhile, variabel of education and unemployment has negative and significant effect of poverty.