This study aims to examine the effect of Sale Financing, Profit Sharing Financing, Financing to Deposit Ratio (FDR), and Non Performing Financing (NPF) to Profitability of Bank Pembiayaan Rakyat Syariah in Indonesia. The objects in this study are all Sharia Banks in Indonesia in the period of 2012-2016. The analysis used in this research is multiple linear analysis. The data used for multiple linear analysis with secondary data is the monthly financial statements in the period of 2012 to 2016. The data source is derived from the statistical data of sharia banking of Bank Pembiayaan Rakyat Syariah that has been processed by the Financial Services Authority. The results of this research indicate that partially variable of sale financing has positive and significant influence to ROA of Bank Pembiayaan Rakyat Syariah. Profit Sharing financing has a negative influence on the ROA of Bank Pembiayaan Rakyat Syariah. While the variable of FDR and NPF have not a significant and negative influence on the ROA of Bank Pembiayaan Rakyat Syariah. Simultaneously the variables of Sale Financing, Profit Sharing Financing, FDR, and NPF influence Bank Pembiayaan Rakyat Syariah.