The activity testing of flavonoid compounds as antioxidant and as scavenger of free radical, from the putri malu (Mimosa pudica, Linn) leaves had been performed for prevention liver damage This study used unrandomized control trial method. Ten male Wistar rats with 150- 250 gr of body weight were divided into two groups. Measuring of SGOT and SGPT before treating was taken to determine first level of SGOT and SGPT. Group I as a control group was given with 1 ml aquadest orally for 9 days. Group II as a experiment group was treated 1, 890 gr for each rat/day putri malu (Mimosa pudica, Linn) leaves boiled for 9 days. In the day 10th, both of groups were induced 1 ml/of kg body weight carbon tetrachloride (CCl4) intraperitoneally. Twenty four hours after CCl4-induced, measuring of serum SGOT and SGPT was done. The result showed Statistic test of independent t – test indicated that there was significant difference beetwen control group and experiment group. Grade of rate SGOT and SGPT after treatment of group control more than hight with p<0.001 (p<0.05) so it could be concluded that putri malu (Mimosa pudica, Linn) leaves boiled can be prevent liver damage greated carbon tetrachloride (CCl4) induced.