-femrinal chrodc reDal diseise GIIRD ) is a public health problem in t donesia . The risk of mo$idity and rnortality rD patients \\,il1r TCRD increased 5 - 10x due to decreased gio retular filtralion rate ( GFR ) , an increasc in lhe incidence of acute infection , stroke and heaft ailack ischemia . Smoking and e\posure to cigarelte smoke is one of the risk faclors of TCRD . But how cigarette pathophysiological rrrechanisms in jritiatj g and aggavatc TCRD nol all kno\Mr. Inflamrnalory reacliors jn responsc lo jnjrr), due to reacliye radicals smoke and process chalges ;r lhe structure end funclion of epilhelial cells inlo mesangial cells ( epithelial nlesa gial kanstjlion / EMT ) iu dre kidDcy is thought to be the main mechanism ofchang€s in the structue and filnctioll ofthe kidney giomeruli aud tubules in both One cytokhe responsible for the regulation of inflammatory reactions atrd processes EMT is TGF - pl the kidney . However, to date researoh on the levels of TGF - Bl in patierts PGKT h Yogyakarta has not been done . The design of the study was a case control study with comparisol case I control is eq[al to I : I . Based on a total sample ofat least 44 patients the trumber ofvolunteers involved in this study as matry as 100 people . Cases were patients TCRD defiled by the criteria of Pemefri and as controls were patients tom the same hospital that does trot comply \vith the criteria PGKT . Age ard sex of the cotrtrol goup comparable to the group of cases . IDclusioncriteriawere(l).PatientspGKT(meetclinicalcriteriaandlaboratory);(2) . Citizens RI ; ( 3 ) . 15-75 years old ; ( 4 ) . Wiling to fill informed consent and ( 5 ) . Exclusioo criteria oflhe srudy sample ( I ), Patients with congenital kidney disease; ( 2 ) . Have a history of kidney transpla[tation and ( 3 ) . Was having a menta] disorder . Secondary data dernographics and history of paill patients were take[ from t]re medical record . Maffl- whitney U test was used to compare the l€vels of TGFPI between the cases [ith a conhol group of smokers and flotr -smokers . The results shoued that the levels ofTGF - P ooPGKT lower than dle levels ofTGI - 81 ' in NON PGKT TGF-Bl levels in smokers is lower lhan the levels of TGF - Bl on the respondents were not srnokers . There is a relationship betwgen smoking aod levels of TGI - b levels . It can be concluded that ttre levels of TGF - 81 in PGKT and lowor smokers . There is a relationship between habit decreased levels ofTGF - BL