This research was aimed to know the influence of third-party funds, financing, Non Performing Financing (NPF), operating costs and operating income, gross domestics products, BI rate, and inflation toward the decline of profitability level in non-foreign exchange sharia banks in the year period of 2011-2016. Profitability is a ratio used to assess a bank’s ability in getting profits calculated by return on asset ratio (ROA). The analysis technique carried out in this research was multiple linear regression and hypothesis test using f test and t test; in addition, classic assumption test and descriptive analysis were also used in this research. The statistical test results indicate that the variable of third-party funds and financing positively influence the return on asset ratio (ROA), while the non performing variable, operating costs and operating income, and inflation give significant positive influence toward the return on asset ratio (ROA).On the contrary, the gross domestics products and BI rate variables do not have any influence toward the return on asset ratio (ROA). The findings of the research simultaneously show that all independent variables have significant influence toward the return on asset ratio (ROA).