This study aims to analyze the effect of Operational Costs and Operating Income (BOPO), Mudharabah, and Murabahah on Profitability (ROA) in the first quarter of 2010 fourth quarter of 2017. The profitability is a specific measure of the appearance of a bank, which is the goal of corporate management by maximizing shareholder value. ROA is used to demonstrate the ability of banking management to manage available capital for profit. The analysis technique used is multiple linear regression analysis and hypothesis test using F test and t test. In addition, the classical assumption test includes normality test, autocorrelation test, heterokedasitas test, linearity test and multicolinearity test. Based on the research that has been done can be concluded that statistical test result of BOPO variable have negative and significant effect to profitability level (ROA), mudharabah variable have positive and significant effect to profitability level, and murabaha variable have negative and significant effect to profitability level.