Background: Indonesia has high burden of tuberculosis and environment that promotes tuberculosis transmission, from adults to children. Bacteriological confirmation of pediatric tuberculosis remains difficult due to unavailability of diagnostic facilities, difficulties in obtaining samples, and poor performance in smear microscopy. Scoring table has been used to help with the diagnosis, yet it lacks sensitivity and spesificity. Purpose: This study was done to view the output of anti-tuberculosis therapy done to patients with score ≥6 and patients with score less than 6 in Panembahan Senopati Hospital. Methods: This study used analytic observtional approach with retrospective cross-sectional design. Sampling method used was consecutive sampling. Obtained data was analyzed using independent t test and chi-square. Results: Seventy three data of tuberculosis patients in 2014, 2015, and 2016 were obtained in February 2017. The results from data analysis suggests that there are no significant difference between both groups' output; with mean weight increment 2.3kg in patients with score ≥6 and 2.234kg in patients with score less than 6 (p=0.986) and improvement of all clinical symptoms; cough, fever, lymph node enlargement and chest x-ray. Conclusion: There are no significant differences of anti-tuberculosis output in both groups. Anti-tuberculosis therapy is allowed to be given considering clinical symptoms and areas with high prevalence of tuberculosis.