Backgrounds: Knowledge and skills of therapeutic communication between dentist and patient plays an important role in the success of dental health treatment, improving the effectiveness of dental health services and patient satisfaction. The success of dental health services to patients, in addition to professional technical expertise required of a dentist and required of non-technical ability, such as therapeutic communication. The effort to improve knowledge and skills of therapeutic communication among the clinical students with patients in the academic dental hospital UMY become increasingly important. Aim: The objective of this study is to assess the relationship between knowledge level of therapeutic communication and doctor-patient communication skills among the clinical students in the academic dental hospital UMY. Method: This study is an analytic observational study with cross sectional design and conducted at the academic dental hospital UMY, involving 105 samples selected by simple random sampling method. The data were obtained from quesioner for therapeutic communication knowledge and checklist for the therapeutic communication skill. Result: The result of Spearman analysis showed p value 0.000 and strong relationship between two variables with coefficient correlation 0,574. Conclusion: There is a relationship between knowledge level of therapeutic communication and doctor-patient communication skills among the clinical students in the academic dental hospital UMY.