Fire protection systems in buildings must be managed, supervised, and controlled properly to avoid the risk of fire. Fulfillment and adjustment to the fire protection system against applicable terms and conditions is required to manage, monitor and control the system properly. The campus building of Universitas Muhammadiyah Yogyakarta (UMY) has the potential to experience fire, because it there are combustible materials and fire-causing components, so it is necessary to do an assessment on fire protection system that is on the management, supervision and control of fire protection system in the building. This research is done to follow up the matter. Research type used in this research is descriptive research type with quantitative approach, research data obtained from result of building assessment and interview owner / manager of building. The results obtained from this research are the level of reliability of management, supervision and control of protection system in Building E6, E7, Postgraduates and F3 at UMY. The analysis performed gives the percentage respectively 59.52% (E6 and E7), 58.03% (Postgraduates), and 56.80% (F3) in terms of management and the reliability level is deficient, while in terms of supervision and identification of each building gets the same percentage of 69.07% and the reliability level is sufficient.