Role of Binahong (Anredera cordifolia (Ten.) Steenis) leaves as hepatoprotector and antioxidant was identified on CCl 4 – induced white rats. Unrandomized control trial method was used in this study. Ten male Wistar white rats with 200 – 250 gr of body weight were divided into two groups. Group I as a control group was treated with standard food and 1 ml aquadest orally for 12 days. Group II as a treatment group was given standar food and daily single dose pretreatment of Binahong (Anredera cordifolia (Ten.) Steenis) leaves juice 289,8 mg/200 gr of body weight for 12 days. Carbon tetrachloride (1 ml/kg body weight, i.p.) injected into rats in the day 13 th to induce liver cells damage. ALP test used ALP KIT reagent had been done twice, 1 st day and 14 th day. The result shows mean of ALP level before and after treatment in control group were 95,94 +1,52 and 110,15 +1,07; in treatment group were 92,65 +3,05 and 92,91 +0,68. Paired T-test shown significant difference before and after treatment (p<0,05). Independent T test shown a significant difference ALP increasing between two group, while ALP serum level in treatment group lower than control group. This study proved that Binahong (Anredera cordifolia (Ten.) Steenis) leafs juice 289,8 ml / 200gr body weight each day could decrease hepatotoxicity effect of carbon tetrachloride by maintain normal level of ALP in white rats Wistar strain