This study aims to analyze the effect of Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), and Operational Cost to Operating Income (BOPO), to Return on Assets (ROA) of Sharia Commercial Banks registered at Bank Indonesia for 2012-2016 period. In this research the used anaysis is multiple linear regression analysis using Eviews8 program aids. After performing multiple linear regression test, the researcher performs classical assumption test on these data which includes residual normality test, multicolinearity test, autocorrelation test, and heterokedastisity test. Based on the result of multiple linear regression test in time series data, it shows that partially Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), and Operational Cost to Operating Income (BOPO) negatively affect on Return on Assets (ROA) of Sharia Commercial Bank Indonesia. While simultaneous research results show that Capital Adequacy Ratio (CAR), Non Performing Financing (NPF), and Operational Cost to Operating Income (BOPO) together effect on Return on Assets (ROA) of Sharia Commercial Bank in Indonesia