Background: Menopause is a problem experienced for women aged 55-65 years, where most. The more false thoughts of women on menopause the higher the level of anxiety experienced. Many of the factors that affect women's anxiety in the face of menopause, namely knowledge, attitude, family support (husband), environment and emotions. Research Objectives: This study aims to determine the relationship of factors- above factors with women's anxiety in the face of menopause Research Method: This research design is descriptive quantitative with cross sectional approach. Sampling technique using total sampling counted 41 respondents. This study used questionnaires that researchers have adopted from other researchers. The Results: Based on the univariate analysis, most of the women experienced anxiety as much as 26 respondents (63.4%), less than 21 respondents (41.2%), had less than 32 respondents (78.0%) the support of the family (husband) is less than 36 respondents (87.8%), enough environments as many as 32 repsonden (78.0%) and unstable emotions as many as 24 respondents (58.5%). The result of bivariate analysis is known there is no relation between knowledge with anxiety with P value = 0,083> 0,05, there is correlation between attitude with anxiety with P value = 0,006 <0,05, there is no relation between family support (husband) with anxiety with P value = 0,0392> 0,05, there is no relation between environment with anxiety with P value = 0,875 and there is no relation between emotion with anxiety with P value = 0,241> 0,05 woman in face of menopause in Sleman III Sub-District Sleman Regency of Sleman. Conclusion: Among some factors only attitude factors that have relationship with anxiety of woman in facing menopause in Sleman III Sleman Sleman Sub-district Sleman Regency.