| dc.description.abstract | Relapse (tooth movement in its original position) has made undesirable result
of the orthodontic treatment. It became a complex problem in orthodontic
which caused by many potential factors. Eric et al. in 2003 reported that relapse
is commonly caused by intrinsic factor related to periodontal ligament and
alveolar bone, but to some extents, extrinsic factors such as face structure
growth, soft tissue pressure and interdigitation are also believed to influence
the process. Relapse happen immediately after orthodontic appliance removed
and decrease its speed after three days, this movement usually followed by alteration
the amount and distribution of osteoclast. Osteoclast is the multinuclear
cell origin of differentiation granulocyte-macrophage progenitor cell in bone
marrow. It has a function for bone remodeling specifically resorbtion, when it
completed osteoclast will be apoptotic.
One of the strategies to manipulate bone remodeling known in orthodontics
area is by the application of an analogous phosphonate drug to inhibit bone resorption,
e g. bisphosphonate. Biphosphonate risedronate is Nitrogencontaining
bisphosphonate that has an ability to adhere calcium and inhibit differentiation
of osteoclast. In this study, we proposed hydrogel system as described
by Saito and Tabata. Bp-risedronate hydrogel is type of Drug Delivery
System that has local effect on inhibiting resorbtion alveolar bone. | |
