Relapse is tooth movement into its original position which has the same pattern with orthodontic tooth movement. The bone resorption undergo in pressure area with increase osteoclast activity, however in tension area bone formation with osteoblast activity. Bisphosphonates are class of drugs that prevent differentiation and activity of osteoclast that is important to inhibit bone resorption and then is expected inhibit relapse. Bisphosphonate also reported to have straight effect towards osteoblast. Some studies related to the preventive effects of bisphosphonate against bone resorption have been extensively done in dentistry. However, topical administration to result local effect is still problems. Drug delivery technology using drug carrier is considered to be a candidate to overcome the problems because the system is effective to transport pharmaceutical substances into targeted area and affect topical