The Dental and Mouth Hospital of Muhammadiyah University of Yogyakarta is a hospital that serves the general public as well as a place of practice for dentistry students at the Muhammadiyah University of Yogyakarta. RSGM uses an integrated hospital information system and is used by hospital staff, lecturers and students. This study aims to obtain information about the use of information systems while testing and analyzing the acceptance of technology by using the Technology Acceptance Model (TAM), based on previous research using this theory. A survey methodology is used to collect data from 144 respondents. The sensitivity of the questionnaire was achieved by adopting a five-point Likert scale. This study was analyzed using the Partial Least Square method which provides the results of a causal relationship between variables that influence each other.The results showed that Perceptions of Utilization and Perception of Ease of Use affect the Behavioral Intention in the use of hospital information systems at the Dental and Oral Hospital of Muhammadiyah University of Yogyakarta Keyword: technology acceptance model, TAM modified, smartpls, perceived ease of use, perceived usefulness, behavioral intention