Background: Spirituality can give positive impact in cancer patients to find meaning and purpose in the life, but health service is still focus in physical problems. Because of that, the data about spirituality in Indonesia has not been comprehensive Objective: This study aims to know about the correlation of spirituality to depression and quality of life in cancer patients. Method: The research used descriptive analytic with cross sectional approach. The research has been taken total sampling conducted in March to April 2018 with amount of sample about 100 cancer patients who are treated in the Public Hospital Province of West Nusa Tenggara. Data were collected using SWB instruments to assess spirituality, BDI II to assess depression and EORTC QLQ-C30 to assess quality of life in cancer patients. Results: The Research showed that the average of religious well being rate was higher than the existential well being. The statistical test is using pearson test, it showed that spirituality was significantly associated to depression and quality of life with p value 0.01< 0.05. Conclusion: Spirituality can be negative impact to depression and positive impact to quality of life, so the data about spirituality can be attention. Keywords: Spirituality, Depression, Quality of Life, Cancer