Tuberculosis is still a global health problem in the world as well as in Indonesia. Millions of people die and contract tuberculosis every year. Various strategies and efforts are made to reduce the incidence of TB one with health education. Health education for more effective results required an educational media. Audiovisual media and booklets are considered interesting media. This study aimed to determine the effect of health education with audiovisual media and booklet media on the attitude and behavior of caregiver in preventing tuberculosis in family members. The research used quasy experiment approach and one group pretest-posttest with control group design. This research was conducted at 3 health centers in Bantul Regency, with 45 respondents The most significant result of this research is health education with audiovisual media and booklet media can simultaneously improve caregiver attitude and behavior in preventing tuberculosis in family member. Conclusion: that health education with audiovisual media and booklet meda simultaneously can improve caregiver attitude and behavior in preventing tuberculosis in family member. Keywords: Tuberculosis, health education, attitudes and behavior, audiovisual media, booklet media