Breast cancer patients who undergo chemotherapy often experience psycholgic disorders in the form of anxiety. Management of anxiety in general can be pharmacological and non-pharmacological, one of the non-pharmacological management of Progresive Muscle Relaxation and dhikr therapy. The purpose of this study was to analyze the effect of therapy (zhikr) and Progressive Muscle Relaxation therapy with caring approach to the anxiety level of Ca Mamae patients with chemomotherapy. This research use Quasi Experiment design with pretest and posttes with control design, with total sample 44 which is divided into control and intervention group, sampling technique using purposive sampling according to inclusion and exclusion criteria. Analysis of research data using indenpenden t-test samples. The results showed that there was influence of therapy zhikr and Progressive Muscle Relaxation with caring approach to the anxiety level of Ca Mamae patients with chemomotherapy with p value 0,007 <0,05. Conclusion research there is a decrease in anxiety levels before therapy zhikr and Progressive Muscle Relaxation with caring approach to the of Ca Mamae patients with chemomotherapy in Dadi Keluarga Hospital Banyumas. Keywords: Zhikr, Progressive Muscle Relaxation, Caring, Anxiety, Chemotherapy