The purpose of this research is to test and analyze the effect of inflation, exchange rate and interest rate of Bank Indonesia Certificates against Indonesia Composite Index. Dependent variable in this research is Indonesia Composite Index. The independent variables in this study consisted of the inflation, exchange rate and interest rate of Bank Indonesia Certificates. Data taken in this research is data closing price for each independent variable and dependent. The sample used saturated sample and obtained as many as 144 samples. The data used is secondary data with data collection method documentation. The analytical method used in this study using multiple linear regression with E-Views 9.0 application tool. The results showed that simultaneously inflation, the exchange rate of Rupiah and SBI interest rate significantly influence the Indonesia Composite Index while partially inflation has no effect and significant to Indonesia Composite Index, while the exchange rate of Rupiah and SBI interest rate significantly negatively affect the Indonesia Composite Index.