Current business trends are leading to service innovation that is digital, social and mobile. Innovation is imperative for an organization, for it to have a significant market presence to be felt in the business world. In order to realize organizational innovation, an effective strategic role of human resources with courage in decision-making is needed. However, in order to make a decision that is right, a wide range of knowledge extracted from various relevant sources, both inside and outside the organization are needed to be able to achieve organizational innovation. This study is conceptual framework that describes some theoretical approaches linking several variables such as the strategic role of human resources, organizational and individual factors and unified knowledge sharing that can lead to organizational innovation. With the trend toward the all-digital, social and mobile dimensions of service innovations, this paper will look into how the human resources response strategically to deal with them. Relationship with perceived organizational support is also discussed in this paper, as an important component that will strengthen the model.