Free radicals can be caused by exposure of UV rays. Free radicals in the body can be a trigger of many diseases. Photoprotective agent can protected the skin from exposure of UV rays. In addition, antioxidant compound can also reduced a negative impact of free radicals. Red dragon fruit (Hylocereus polyrhizus) was one of the fruits which contain a flavonoid compound. This compound can acted as photoprotective and antioxidant agents. This study aims to know the content of flavonoid in the peel of red dragon fruit (Hylocereus polyrhizus) and knowing the antioxidants and photoprotective activities. The peel of red dragon fruit (Hylocereus polyrhizus) extracted within ethanol then macerate fractionated with ethylacetate. The content of phenolic and flavonoid compounds of ethylacetate fraction of the red dragon fruit (KBNMAcOEt) tested with TLC method, Folin-Ciocalteu method, and chelation AlCl3 method. Furthermore, the free radical (DPPH) scavenging test was be done to found out the antioxidant activities of KBNM-AcOEt and in vitro test with spectrophotometry method was conducted to found out the SPF value of KBNMAcOEt. The Total Phenolic Content of KBNM-AcOEt was 1493,4641 ± 14,9757 mg GAE/100g and the Total Flavonoid Content of KBNM-AcOEt was 16,5278 ± 0,3612 % b/b EQ. Antioxidant activities of KBNM-AcOEt was weak (> 150 μg/mL). It was seen from the IC50 value of KBNM-AcOEt (491.9421 μg/mL). Meanwhile, the SPF value of KBNM-AcOEt was very low (0.0069 ± 0.0071). The KBNM-AcOEt at a concentration of 5, 25, 50 and 100 mg / L does not have photoprotective activities.