| dc.contributor.author | HIDAYATI, TITIK | |
| dc.contributor.author | HABIB, INAYATI | |
| dc.contributor.author | AKROM, AKROM | |
| dc.date.accessioned | 2016-09-22T06:07:26Z | |
| dc.date.available | 2016-09-22T06:07:26Z | |
| dc.date.issued | 2015-07-01 | |
| dc.identifier.other | doi: 10.18178 | |
| dc.identifier.uri | http://repository.umy.ac.id/handle/123456789/2548 | |
| dc.description | article | en_US |
| dc.description.abstract | single and repeated doses of DMBA are toxic to
immune system. Black cumin seed oil (BCSO) is
immunoprotector agent. A study was performed to identify
antiimmunitoxicity effects of BCSO on DMBA-induced SD
mice. This study was conducted with an experimental design
with BCSO administration group and a normal control
group. DMBA induction was administered by two methods:
a single dose of 15mg/mouse per oral (DMBA15group), and
repeated doses of 10 × 20mg/kgb twice/week for 5 weeks
(DMBA20/group). Normal control was a non-DMBAinduced
group while diseased groups were DMBA-induced
groups, DMBA15 and DMBA20. Treatment groups were
DMBA 15 and DMBA 20 which were given 0.25ml/kgBCSO
14 days before and during DMBA induction
(DMBA15BCSO and DMBA20BCSO groups. Observation
was carried out on peripheral blood, spleen histological
description and spleen weight, CD4 and CD4CD25
lymphocyte counts. Results showed that the single and
repeated doses of DMBA in SD mice are
immunosuppressive and hematotoxic. The administration of
0.25ml/kgbwBCSO can decrease the immunosuppressive
and hematotoxic effects of DMBA. The number of leukocyte
and CD4Th in the treatment groups was higher than the
diseased group (p < 0.05). Conclusion: BCSO is the
antihematotoxic immunoprotector for diseased groups. | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | IJPMBS | en_US |
| dc.relation.ispartofseries | Volume 4;Nomor. 3 | |
| dc.subject | DMBA, black cumin seed oil (BCSO), immunotoxic, hematotoxic | en_US |
| dc.title | ANTIIMMUNOTOXIC OF BLACK CUMIN SEED OIL (NIGELLA SATIVA OIL) IN DMBA (DIMETHYLBENZANTRACENE)-INDUCED MICE | en_US |
| dc.type | Article | en_US |
