Background: 35% Hydrogen peroxide used as a material bleaching have negative effects such as wounds if exposed to gingiva. The aimed of this study is to determine the effectiveness of papaya gel extract (Carica Papaya L.) with 75% concentration in accelerate healing of gingival wounds that caused by 35% hydrogen peroxide. Methods: This study was an in vivo laboratory experimental in 33 male strain Sprague Dawley rats (Rattus norvegicus). The samples were divided into 3 groups with each 2 samples drop out, at day 0 all rats induced by 35% hydrogen peroxide with a basting, here in after group I was given Kenalog in orabase, group II was given gel extract and group III was given distilled water. The treatment was done every day and in day 1,3,5 and 7 the rats were taken at random for measuring the diameter of the wound and recapitulation of the jaw. Furthermore, observe the number of macrophages in the preparations. The normality of data were analyzed with Shapiro Wilk because the sample is less than 50. If the data are normally distributed the test will followed by one way ANOVA as the comparative test and using the Least Significant Difference test. Results: The average diameter of the wound for the first group have a smallest diameter, group 2 is wider and group3. The average based on number of macrophage cells, group III have the most machropage cells, followed by group II and group I have least machropage cells, the largest number of macrophage cells is on day 1 and day 3. Saphiro Wilk and One Way Anova test show all data is significant and LSD test that have the highest Mean Difference is in group III in the amount of 1,450. Conclusion: 75% papaya leaf extract gel can accelerate the wound healing process in terms of a reduction in the diameter of the wound and the amount of macrophage cells