The incidence of Tuberculosis disease is a public health problem, although there are standards of therapy and clinical pathway for TB patients. Complications of TB disease will lead to increase mortality and to decrease quality of life of patients. The effectiveness of drug therapy should be enhanced by developing an educational or counseling model as non-pharmacological treatment of primary care. Preparation of that model start with knowing faktors that influence the success of Tuberkulosis therapy in primary care. This step is needed to make the model effective and in accordance with the service condition. The purpose of this research is to know is depression faktor can affect the success of Tuberculosis therapy. The study design was a cohort for 6 months with a total of 57 Tuberculosis patients. Data collection was done in primary by interviewing with questionnaire guidance. Secondary data retrieval was conducted to obtain therapeutic data, clinical outcomes, laboratory and radiology. The results showed patients without depression are 202 times greater to experience successful therapy than those who are depressed. The conclusion showed that there was a significant association between depression faktor and the success of Tuberculosis therapy.