Background : One side effect of the hydrogen peroxide 35% is causing inflammation of the gingiva . Cells contained in the phase of inflamation is lymphocyte cells . The Papaya leaves contains some active compound of saponin , tannins and flavonoids . The active compound of the papaya leaves can be as an anti-inflammatory substance and wound healing Research Objectives : This research aims to determine the effectiveness of papaya leaves extract gel towards amount oflymphocyte cells and wound diameter in the process of wound healing causes by bleaching materials on male rats. Research methods : The research design was purely experimental in vivo. The subject of this research was 33 male rats. The rats given the injury with Hydrogen Peroxide 35% using microbrush. The subject which were divided into three treatment groups. The first group is (kenalog) as a positive control, the second group (papaya leaves extract gel 75%), the third group is (Aquades) as a negative control. The treatment was done every day and in day 1,3,5 and 7 the rats were taken at random for measuring the diameter of the wound and recapitulation of the jaw. The preparat of tool was colored by HE. Furthermore, observe the number of lymphocytes in the preparations. Data analysis was using the Shapiro Wilk normality test, and the it was tested by using the hypothesis One Way Anova, and advanced testing with theLeast Significant Differences. Results : There are tworesults in this research which iswound diameter and the amount of lymphocytes cells . The Shapiro Wilk normality test results ( p - value> 0.05 ), it indicates that the data has normal distribution of data . One Way Anova test results significance value of 0.039 ( p - value < 0.05 ) , it means there is a differences in the number of lymphocytes among the three groups , the test results obtained Least Significant Differences lymphocyte cell counts significantly in group II ( Gel papaya leaf extract 75 % ) Conclusion : The provision of papaya extract gel concentration of 75% effective to decrease the number of lymphocytes and the diameter of the wound in the process of wound healing causes by bleaching materials in male rats( p < 0.05 ) .