This study aims to learn the effect of various varieties and types of irrigation on growth, yield and physiology of rice plants. This research was carried out on the experimental field of Muhammadiyah University of Yogyakarta in August-December 2018. This research was carried out in a field with a 2x4 factorial strip-plot design arranged in a Completely Block Randomized Design with 3 replications so that 24 research units were collected. Factor I consists of 2 levels, namely A1 (intermittent irrigation) and A2 (continuous irrigation). Factor II consisted of 4 levels, namely IR-64 (VIR), Mentik Wangi (VMW), Cianjur (VCI), and Segara Anak (VSA) varieties. Parameters observed were plant height, number of tillers, fresh weighted weights and dry weighted weights, leaf area, root length, grain weight, 1000 grain weight, grain yield per hectare, crop growth rate, relative growth rate, net assimilation rate, and specific leaf weights. The results showed that the treatment of varieties affected plant height, fresh weighted weight and dry weight. Rice from mentik fragrant varieties had an influence on plant height. Cianjur variety rice has an influence on fresh weighted weight and dry weight of plant weight. The yield of rice can be seen from the weight of grain / clump and panicle length, namely the Cianjur variety. In physiology there is no effect on varieties. The irrigation treatment showed an effect on fresh weighted weight and dry weighted plant weight, while the physiology and yield had no effect. In the parameters of panicle length and grain / clump weight there is an interaction between varieties and irrigation. The treatment of SRI irrigation with the Cianjur variety showed a significantly higher effect than the Mentik Wangi variety, Segara Anak, and IR64.